Get everything ready! Bring a large pot of generously salted water to a boil for your fettuccine. While waiting, pat your shrimp, scallops, and mussels dry with paper towels—this helps them sear beautifully.
Sauté the aromatics Heat olive oil in a large skillet over medium heat. Add chopped onion and cook for 3-4 minutes until soft and translucent. Toss in the minced garlic and red pepper flakes (if using), stirring for about 1 minute until fragrant—your kitchen will smell amazing!
Build the sauce base Pour in the white wine and let it bubble for 2 minutes to reduce slightly and cook off the alcohol. Add the crushed tomatoes with their juices, season with salt and pepper, and simmer gently for 8-10 minutes to let the flavors meld.
Cook the pasta Add the fettuccine to the boiling water and cook until al dente (usually 1-2 minutes less than package directions). Reserve 1 cup of pasta water, then drain the pasta.
Add the cream for luxury Stir the heavy cream into your simmering tomato sauce. Let it gently bubble for 3-4 minutes until it thickens slightly into that gorgeous creamy pink color.
Introduce the seafood Add the mussels first (they take longest), cover the pan for 3-4 minutes until they open. Discard any that don't open. Then gently add the shrimp and scallops, cooking for 3-4 minutes until the shrimp are pink and opaque and scallops are just firm.
Combine everything Toss the drained fettuccine directly into the skillet with the sauce and seafood. Add a splash of reserved pasta water if needed to create a silky coating.
Finish with cheese and herbs Sprinkle in the grated Parmesan, chopped basil, and parsley. Gently toss until the cheese melts and everything is coated in creamy goodness.
Taste and adjust Give it a quick taste—add more salt, pepper, or a squeeze of lemon if desired for brightness.
Serve and enjoy! Plate immediately, garnishing with extra Parmesan and fresh herbs. Dive in while it's hot and steamy—buon appetito!